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Fungal Mycelium Supplement Tied to Fewer COVID-19 Vaccine Side Effects and Longer Antibody Response

UC San Diego’s small randomized trial reports safety with durability signals in need of larger confirmation.

Overview

  • The double-blind, placebo-controlled study of 90 adults, published March 3 in BMC Immunology, tested a four-day oral course starting on vaccination day.
  • The supplement, called FoTv, is derived from the mycelium of Fomitopsis officinalis and Trametes versicolor.
  • Participants without prior COVID-19 who received FoTv reported significantly fewer short-term side effects than those on placebo.
  • In the COVID-naive subgroup, antibody levels continued to increase over six months rather than declining after the typical one-month peak.
  • No adverse events were reported, and investigators highlight scalable manufacturing and propose further evaluation for broader vaccine support, including potential future threats such as H5N1.