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France Authorizes Fully Reimbursed Apretude, a Long-Acting HIV PrEP Injection

Full coverage follows lengthy price negotiations, highlighting unresolved limits on who can receive it.

Overview

  • An order published in the Journal officiel on February 26 authorizes cabotegravir (Apretude) for sale in France and classifies it for full health insurance reimbursement as “irreplaceable and particularly costly.”
  • Apretude is administered by injection every two months, offering an alternative for people who struggle to adhere to daily oral PrEP.
  • The Haute Autorité de Santé validated the drug’s interest in 2024 but rated its medical benefit as moderate and does not recommend it for women of childbearing potential due to a potential fetal malformation risk.
  • Commercial rollout followed protracted price talks with ViiV Healthcare; the company’s list price exceeds €1,000 per dose, while the reimbursed amount remains confidential.
  • Advocacy group Aides welcomed the approval as a major step but warned patients may face out-of-pocket costs for a required HIV viral load test that is not covered at 100%.