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Family Guy Marks 450th Episode With First-Ever LoisStewie Conversation

Showrunners present the milestone as a self-contained experiment powered by a cheeky premise, as Alex Borstein praises its emotional resonance.

Overview

  • Fox aired the Season 24 premiere, “The Edible Arrangement,” as the series’ 450th episode on Feb. 15 at 9:30 pm ET.
  • For the first time, Lois and Stewie share a direct conversation, triggered by a gummy-driven setup from Quahog’s newly legal dispensary.
  • Alex Borstein called making the episode extremely therapeutic and her favorite, noting its personal meaning to her as a mom.
  • A PaleyFest live table read of the script drew an enthusiastic reaction, giving Borstein a rare chance to perform opposite Seth MacFarlane.
  • Showrunners say the story was refocused from a Peter–Stewie pairing to Lois for deeper emotion and is intended as a one-off, even as Borstein says it sparked ideas the writers are considering.