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Experimental Pill Doubles Survival in Advanced Pancreatic Cancer Trial

A targeted pill blocking a common tumor protein could reach patients after regulatory review.

Overview

  • Revolution Medicines reported that daraxonrasib patients lived a median 13.2 months versus 6.7 with standard second-line chemotherapy in a study of about 460 people.
  • The once-daily oral drug is designed to block a protein mutated in more than 90% of pancreatic cancers, offering a targeted approach.
  • Participants had advanced disease after prior chemotherapy, with half assigned to the pill and roughly 60 patients enrolled in France.
  • Trial lead Dr. Brian Wolpin said the results mark a major advance that could change care for previously treated metastatic cases.
  • French specialists said European access could come within months to two years, pending regulatory review and publication of full data.