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Eric Dane, Star of Grey’s Anatomy and Euphoria, Dies at 53 After ALS Battle

His family said he spent his final hours with loved ones after a year of public advocacy for ALS research.

Overview

  • His death on Thursday was confirmed in statements shared by his family and representatives, who cited amyotrophic lateral sclerosis.
  • Diagnosed publicly in April 2025, Dane described fast-progressing symptoms in subsequent months as he continued to work and speak about the disease.
  • He is survived by his wife, Rebecca Gayheart, and their daughters, Billie and Georgia, and the family asked for privacy.
  • Dane was best known for playing Dr. Mark Sloan on Grey’s Anatomy and Cal Jacobs on HBO’s Euphoria, and he completed work for Euphoria’s third season, scheduled to arrive in April.
  • He became an outspoken advocate tied to groups such as I AM ALS, met lawmakers in Washington, and portrayed an ALS patient on NBC’s Brilliant Minds, withdrawing from a January ALS gala due to health.