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Eric Dane, ‘Grey’s Anatomy’ and ‘Euphoria’ Actor, Dies at 53 From ALS Complications

His family said he died Thursday after a year of public advocacy that followed his April 2025 ALS disclosure.

Overview

  • Representatives confirmed Dane died on February 19 from complications of ALS, saying he passed peacefully among close friends, his wife Rebecca Gayheart, and daughters Billie and Georgia, and requesting privacy.
  • After revealing his diagnosis in April 2025, his condition progressed quickly, with media reports noting wheelchair use and speech difficulties by October.
  • Dane became a prominent voice for ALS awareness and research during the past year and received an ALS Advocate of the Year recognition in September 2025.
  • He was widely known for portraying Dr. Mark Sloan on Grey’s Anatomy and Cal Jacobs on HBO’s Euphoria, with other credits including The Last Ship and X‑Men: The Last Stand.
  • A posthumous memoir titled Book of Days is expected in 2026 with Maria Shriver’s involvement, and outlets report he will appear in Euphoria’s forthcoming third season.