Overview
- Researchers reported in PNAS that engineered SimCells and mini‑SimCells wiped out most of a multidrug‑resistant E. coli strain in lab dishes, with mini‑SimCells clearing over 97% within 48 hours.
- The cells use surface nanobodies to latch onto specific bacteria and a Type VI secretion system to inject a lethal toxin.
- Mini‑SimCells add a second hit by converting a small dose of aspirin into hydrogen peroxide at the infection site.
- In mixed‑culture tests, the engineered cells spared non‑target bacteria while eliminating the intended pathogen.
- The work remains preclinical, and with antimicrobial resistance tied to nearly five million deaths a year, upcoming tests in animals and studies of immune response will determine if this approach can move toward patients.