Overview
- In a peer‑reviewed study, bioactive supramolecular nanoparticles repaired the blood–brain barrier and reactivated LRP1 transport in mouse models of Alzheimer’s.
- One hour after a single injection, brain amyloid‑β levels dropped by roughly half, and a three‑injection regimen produced sustained effects.
- Treated mice showed improved spatial learning and nest‑building, with benefits persisting for at least six months in older animals.
- The nanoparticles acted as drugs rather than carriers by engaging LRP1 ligands to reset receptor trafficking and vascular health.
- Researchers from UCL, IBEC and West China Hospital published the findings in Signal Transduction and Targeted Therapy, as outside experts urged caution about translation to people.