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Edinburgh Scientists Make Parkinson’s Drug From Waste Plastic in Lab Proof of Concept

Engineered E. coli converted PET‑derived terephthalic acid into L‑DOPA in work published in Nature Sustainability.

Overview

  • The University of Edinburgh reports the first biological conversion of plastic waste into a therapeutic for a neurological disease.
  • Researchers depolymerized PET into terephthalic acid, then used engineered E. coli to synthesize L‑DOPA through programmed reactions.
  • The team presents the approach as a greener alternative to fossil‑fuel‑based pharmaceutical manufacturing with prospects for bio‑upcycling.
  • The result remains a laboratory‑scale demonstration, with next steps focused on improving yield and speed and evaluating cost and environmental performance before any industrial deployment.
  • The study was conducted at the Carbon‑Loop Sustainable Biomanufacturing Hub with support from Edinburgh Innovations and funding from UKRI and IBioIC, highlighting PET’s roughly 50‑million‑tonne annual production as a vast potential feedstock.