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Ebola Outbreak in DR Congo Reaches 1,406 Cases as WHO Greenlights Treatment Trials

Because the outbreak is driven by the Bundibugyo variant that has no approved vaccine or therapy, WHO has moved to test experimental monoclonal and antiviral drugs to try to slow spread

Overview

  • Health authorities reported Thursday that the outbreak has produced 1,406 confirmed cases and 438 deaths, a 31.2% case fatality rate concentrated mainly in Ituri province.
  • WHO has activated an international alert and opened enrollment for trials that will test an experimental monoclonal antibody and an antiviral, with studies coordinated by the DRC’s National Institute for Biomedical Research.
  • The virus has spread beyond the epicenter with a newly confirmed case in Kisangani and roughly 20 cases, including two deaths, reported in neighboring Uganda, raising cross‑border containment concerns.
  • Response work has been hampered by slow lab confirmation of samples, deep public distrust and violence, including the burning of a treatment center in Nia Nia and the escape of seven suspected cases.
  • International groups are sending experimental treatments and CEPI has committed funds to develop Bundibugyo-specific vaccines, but experts warn that trials will take months and success will depend on more lab capacity, sustained funding and community trust.