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Early Trial of VIR-5500 Shrinks Tumors in 45% of Advanced Prostate Cancer Cases

Investigators plan larger studies following promising early signals.

Overview

  • Researchers presented data at the ASCO Genitourinary Cancers Symposium from 58 men with treatment‑resistant disease.
  • Tumor shrinkage was reported in roughly 45% of participants.
  • In the highest‑dose group of 17 patients, 53% saw a 90% PSA decline and 82% had PSA levels cut by half.
  • Reported side-effects were mostly mild, with 88% experiencing only very mild symptoms.
  • VIR‑5500 is a tumor‑activated T‑cell engager with a cloaking design; the Vir Biotechnology–funded, early‑phase results now move to larger, confirmatory trials.