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Early-Onset Colorectal Cancer Surges, Prompting Fresh Calls for Screening at 45

Rising diagnoses now make it the leading cancer killer under 50.

Overview

  • New analyses and clinical reporting cite the American Cancer Society’s finding that colorectal cancer is now the top cause of cancer death in Americans under 50.
  • Doctors say incidence is rising about 3% each year in people 20–49, with many cases found later and higher burdens in Black, Native American and some Asian Pacific Islander communities.
  • Rectal tumors now represent roughly one‑third of cases, and warning signs include bright red bleeding, left‑sided abdominal pain and an unproductive urge to defecate.
  • Guidelines advise average‑risk adults to begin screening at 45, with colonoscopy the gold standard, and early detection delivering five‑year survival rates above 90%.
  • Clinicians warn younger patients’ symptoms are often dismissed and urge self‑advocacy, while flagging modifiable risks tied to diet, obesity, alcohol, smoking and other lifestyle factors.