Overview
- Djokovic advanced to the last eight after Jakub Mensik withdrew with an abdominal injury.
- Aryna Sabalenka beat Victoria Mboko 6-1, 7-6 (7/1) to reach the quarterfinals, extending her run of consecutive Grand Slam tie-break wins to 20 to equal Novak Djokovic's Open Era mark.
- Carlos Alcaraz defeated Tommy Paul 7-6, 6-4, 7-5 and will face Alex de Minaur in the quarterfinals.
- American 20-year-old Learner Tien ousted Daniil Medvedev 6-4, 6-0, 6-3 to become the youngest Melbourne quarterfinalist since 2015, setting up a meeting with Alexander Zverev.
- Defending champion Madison Keys fell to Jessica Pegula 6-3, 6-4 in the round of 16.