Overview
- In Nature Medicine on March 9, researchers report that two years of multivitamin use slowed biological aging by about four months versus placebo.
- The yearly rate of increase fell on two mortality‑linked epigenetic clocks—PCPhenoAge (~2.6 months) and PCGrimAge (~1.4 months)—while three other clocks showed no significant change.
- Benefits were greater for participants already aging faster biologically at baseline, especially on PCGrimAge.
- The randomized blood subcohort included 958 healthy adults with a mean age near 70, most of whom were White, which may limit generalizability.
- Cocoa extract showed no effect on any clock, and investigators disclosed support from Haleon and Mars and plan follow‑up to assess durability and links to health outcomes.