Overview
- Surgeons at the Second Affiliated Hospital of Guangxi Medical University transplanted a six‑gene‑edited pig liver and both pig kidneys into a 53‑year‑old brain‑dead donor and monitored graft function for about 106 hours.
- The porcine organs began working quickly with bile secretion and urine production and overall blood flow appeared largely normal, indicating substantial physiological compatibility with the human body.
- Investigators detected signs of immune activation roughly 36 hours after surgery, including elevated S100A12+ immune cells and small areas of tissue death and clotting in the liver.
- The team reported coagulation instability and a limited observation window set by the family, and the authors said they plan three to five more procedures to assess reproducibility and longer‑term outcomes.
- The study builds on prior Chinese single‑organ xenotransplants and highlights key next steps for the field: extended follow‑up, infection screening, targeted immunosuppression and broader safety testing before use in living patients.