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Cannabis Use Disorder Triples Five-Year Oral Cancer Risk; Tobacco Co-Use Raises It Sixfold

Carcinogens in cannabis smoke triple oral cancer odds within five years, with no elevated risk detected for non-combustible cannabis products.

Overview

  • Patients diagnosed with cannabis use disorder had three times higher odds of developing oral cancer within five years than those without the disorder.
  • Tobacco smokers with cannabis use disorder faced a more than sixfold increase in oral cancer risk compared to smokers without cannabis addiction.
  • Researchers analyzed records from 45,129 patients, including 949 with a formal CUD diagnosis, adjusting for age, sex, body mass index and smoking status.
  • The study highlights that combustion byproducts in cannabis smoke mirror known tobacco carcinogens that damage the mouth’s epithelial lining.
  • Edibles and other non-combustible cannabis products did not show a measurable link to elevated oral cancer risk.