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Axsome Reports 57% Q1 Sales Jump as FDA Clears Auvelity for Alzheimer’s Agitation

Profit lags as Axsome prioritizes launch spend plus R&D.

Overview

  • Axsome, which reported first‑quarter results Monday, booked $191.2 million in product revenue, up 57% year over year across Auvelity, Sunosi, and Symbravo.
  • The FDA recently approved Auvelity to treat agitation in Alzheimer’s dementia, with a U.S. launch planned in June, and management now pegs the drug’s long‑term peak sales at at least $8 billion.
  • To support the rollout, the company expanded its field force to about 630 sales reps and says commercial and Medicare payers now cover roughly 86% of lives.
  • Higher operating costs drove a $64.5 million net loss as selling, general and administrative expense rose to $185 million and R&D reached $52.7 million, and shares pulled back Monday on the wider‑than‑expected loss.
  • Axsome ended the quarter with about $305 million in cash, filed an FDA application for AXS‑12 in narcolepsy, and added AXS‑20 for schizophrenia and Tourette syndrome through an April acquisition.