Overview
- The tie at St Mary's kicks off Saturday at 20:00 BST and airs live on BBC One and TNT Sports, with streams on BBC iPlayer and HBO Max.
- Arsenal top the Premier League and still target a treble after their League Cup final loss, but injuries and international withdrawals point to rotation and a possible start for 16-year-old Max Dowman.
- Southampton arrive unbeaten in 14 matches and as the last Championship side left, having ousted Fulham after January moves for Cyle Larin and Daniel Peretz steadied the team.
- Flynn Downes and Kuryu Matsuki are suspended for Southampton, captain Jack Stephens is a doubt, and Leo Scienza is being eased back from a groin problem.
- Gabriel Martinelli has four goals and an assist in this season's FA Cup, the best return since the third round, and bookmakers still back Arsenal even as many see a live upset risk.