Overview
- A Nature paper published June 17, 2026 reconstructed the oldest known plague genomes from teeth and detected Yersinia pestis DNA in 18 of 46 individuals from four Lake Baikal cemeteries.
- Radiocarbon dating and family relationships in the graves indicate two separate outbreaks beginning about 5,500 years ago and that many deaths occurred in a short span among siblings and parents with children disproportionately affected.
- Genomic analysis shows these ancient strains lacked the ymt gene needed for flea‑borne bubonic spread but carried a previously unseen superantigen gene that can trigger extreme immune responses and likely raised lethality.
- Archaeological finds and the region’s ecology point to marmots as the most likely wild‑rodent reservoir, with initial spillover from butchery or handling followed by probable human‑to‑human respiratory transmission.
- The study pushes back the earliest confirmed plague outbreaks by roughly 200 years, narrows the bacterium’s early evolution window, and changes models of zoonotic emergence without implying new immediate public‑health risks.