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9h ago

49ers Slight Road Favorites Over Giants in Week 9 at MetLife

Odds tilt toward San Francisco with an unusually high total, reflecting confidence in its playmakers and New York’s backfield loss of Cam Skattebo.

Will Christian McCaffrey and the San Francisco 49ers beat the New York Giants on Sunday? Will they cover the point spread? NFL Week 9 predictions, picks, odds preview the game on Nov. 2, 2025.

Overview

  • San Francisco (5–3) visits New York (2–6) on Sunday, Nov. 2, at MetLife Stadium in an NFL Week 9 matchup.
  • Sportsbooks list the 49ers around −2.5 with San Francisco favored on the moneyline and the over/under near 48.5 points.
  • FanDuel and other books post the highest projected total of the 49ers’ season to date, signaling expectations for more scoring than usual.
  • The Giants will play their first game without rookie running back Cam Skattebo, who is out for the season with a dislocated ankle.
  • Brock Purdy’s potential return from a toe injury remains a developing storyline as rookie Jaxson Dart continues an up‑and‑down stretch for New York.